Baffled By The Boss

What do you do when your boss doesn't like to be "bothered" but you have something that needs to be answered from them?  You can't physically bog them down so you email them but they don't respond to the email.  You text but they don't respond.  You're uncomfortable asking them in person more then four times.    

Really if they don't answer, you can't answer, and sometimes or most times, that is a reflection on the company.  You'd think the boss would understand that.  

So what is your effective way to get the message across to them?